ChemicalBook--->CAS DataBase List--->129121-73-9

129121-73-9

129121-73-9 Structure

129121-73-9 Structure
IdentificationBack Directory
[Name]

ALPHA-CGRP (8-37) (RAT)
[CAS]

129121-73-9
[Synonyms]

CGRP 8-37 (RAT)
Rat CGRP-(8-37)
PubChem ID: 90479762
RAT CGRP-(8-37)?, >98%
ALPHA-CGRP (8-37) (RAT)
α-CGRP (8-37) (mouse, rat)
a-CGRP (8-37) (Mouse, rat)
Alpha-CGRP (8-37) (mouse, rat)
VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2
CALCITONIN GENE RELATED PEPTIDE (8-37) RAT
Rat CGRP-(8-37),VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF
Calcitonin Gene Related Peptide (CGRP) (8-37), rat
ALPHA-CALCITONIN GENE-RELATED PEPTIDE (8-37) (RAT)
Rat CGRP-(8-37),VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF, >98%
Alpha-CGRP (8-37) (mouse, rat) trifluoroacetate salt
α-CGRP (8-37) (mouse, rat)|Calcitonin Gene Related Peptide (8-37),rat
α-CGRP (8-37) (mouse, rat),Calcitonin Gene-Related Peptide I (8-37) (mouse, rat), CGRP-I (8-37) (mouse, rat)
VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2
H-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2
α-CGRP (8-37) (canine, Mouse, rat) Calcitonin Gene-Related Peptide I (8-37) (canine, Mouse, rat), CGRP-I (8-37) (canine, Mouse, rat)
Calcitonin Gene-Related Peptide I (8-37) (canine, Mouse, rat), CGRP-I (8-37) (canine, Mouse, rat), Calcitonin Gene-Related Peptide I (8-37) (Mouse, rat), CGRP-I (8-37) (Mouse, rat)
Biotinyl-Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-GlyLeu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-ThrAsn-Val-Gly-Ser-Lys-Ala-Phe-NH2trifluoroacetatesalt(Disulfidebond)
ALA-CYS-ASP-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2: ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2DISULFIDE BRIDGE CYS2-CYS7
[Molecular Formula]

C138H224N42O41
[MDL Number]

MFCD00671419
[MOL File]

129121-73-9.mol
[Molecular Weight]

3127.51
Chemical PropertiesBack Directory
[density ]

1.47±0.1 g/cm3(Predicted)
[storage temp. ]

-20°C, protect from light
[solubility ]

H2O : 50 mg/mL (15.99 mM; Need ultrasonic)
[form ]

Solid
[color ]

White to off-white
[Water Solubility ]

Soluble to 1 mg/ml in water
[Sequence]

H-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-OH
Hazard InformationBack Directory
[Uses]

Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist.
[in vivo]

CGRP-(8-37) is effective in alleviating mechanical and thermal allodynia in a dose-dependent manner. The 50 nM dose is most efficacious for both forelimb and hindlimb responses. The period of efficacy is 10 min to onset for a duration of 20 min. Post-drug washout responses are not statistically significant compared to pre-drug responses[1]. Intrathecal administration of 5 nmol or 10 nmol of CGRP-(8-37), but not 1 nmol, induces a significant increase in hindpaw withdrawal latency. Intrathecal administration of CGRP-(8-37) not only reverses the SP-induced decrease in latency to both withdrawal responses but also mediates a significant increase in response latency compared to basal levels[2].

[storage]

-20°C, protect from light
[References]

[1] Bennett AD, et al. Alleviation of mechanical and thermal allodynia by CGRP(8-37) in a rodent model of chroniccentral pain. Pain. 2000 May;86(1-2):163-75. DOI:10.1016/s0304-3959(00)00242-6
[2] Yu LC, et al. The calcitonin gene-related peptide antagonist CGRP8-37 increases the latency to withdrawalresponses in rats. Brain Res. 1994 Aug 8;653(1-2):223-30. DOI:10.1016/0006-8993(94)90393-x
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