| Identification | Back Directory | [Name]
Propargyl-PEG3-phosphonic acid ethyl ester | [CAS]
1052678-30-4 | [Synonyms]
Propargyl-PEG3-Phosphonic Ester
Propargyl-PEG3-phosphonic acid ethyl ester
Propargyl-PEG3-phosphonic acid diethyl ester
Phosphonic acid, P-[2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]ethyl]-, diethyl ester | [Molecular Formula]
C13H25O6P | [MDL Number]
MFCD31380397 | [MOL File]
1052678-30-4.mol | [Molecular Weight]
308.31 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG3-phosphonic acid ethyl ester is a crosslinker containing a propargyl group and a phosphonic acid ethyl ester. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
Propargyl-PEG3-phosphonic acid diethyl ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Propargyl-PEG3-phosphonic acid diethyl ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] Thorsten Heidelberg, et al. Oligo-ethylene glycol based phosphonate surface modification reagents and use thereof. WO2015065168A1 |
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