| Identification | Back Directory | [Name]
Propargyl-PEG4-5-nitrophenyl carbonate | [CAS]
1422540-81-5 | [Synonyms]
Propargyl-PEG4-5-nitrophenyl carbonate
2,5,8,11,14-Pentaoxaheptadec-16-ynoic acid, 4-nitrophenyl ester | [Molecular Formula]
C18H23NO9 | [MDL Number]
MFCD29041851 | [MOL File]
1422540-81-5.mol | [Molecular Weight]
397.38 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG4-5-nitrophenyl carbonate is heterobifunctional reagent with a propargyl group and nitrophenyl group. The propargyl group enales the formation of triazole linkage with azide compounds or biomolecules via copper catalyzed Click Chemistry. Nitrophenyl group is reactive towards the amino group of lysine by means of stable urethane linkages. The PEG units enhance the solubility of the molecule in aqueous media. | [Uses]
Propargyl-PEG4-5-nitrophenyl carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-5-nitrophenyl carbonate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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