| Identification | More | [Name]
5-METHYLBENZOXAZOLE | [CAS]
10531-78-9 | [Synonyms]
5-METHYL-1,3-BENZOXAZOLE
5-METHYLBENZOXAZOLE
5-Methylbenzoxazole, 99.5+% | [Molecular Formula]
C8H7NO | [MDL Number]
MFCD00216938 | [Molecular Weight]
133.15 | [MOL File]
10531-78-9.mol |
| Chemical Properties | Back Directory | [Appearance]
YELLOW TO BROWN CRYSTALLINE SOLID | [Melting point ]
41-44 °C | [Boiling point ]
96 °C / 15mmHg | [density ]
1.1475 (rough estimate) | [refractive index ]
1.5320 (estimate) | [Fp ]
87℃ | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [pka]
2.66±0.10(Predicted) | [color ]
White to Green to Brown | [CAS DataBase Reference]
10531-78-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,C | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R37/38:Irritating to respiratory system and skin .
R36:Irritating to the eyes.
R34:Causes burns.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S27:Take off immediately all contaminated clothing . | [WGK Germany ]
1 | [HS Code ]
29349990 |
| Hazard Information | Back Directory | [Chemical Properties]
YELLOW TO BROWN CRYSTALLINE SOLID | [Synthesis]
GENERAL METHOD: Triethyl orthoformate (1.1 mmol) and o-amino-p-toluol (1 mmol) were mixed and p-toluenesulfonic acid (TSA, 1 mol%) was added as a catalyst. The reaction mixture was stirred at 80-90 °C for an appropriate time depending on the course of the reaction (cf. Table 4). After completion of the reaction (monitored by TLC), the reaction mixture was diluted with chloroform (10 mL) and the catalyst was removed by filtration. The final product 5-methylbenzazole was purified by column chromatography. | [References]
[1] Monatshefte fur Chemie, 2011, vol. 142, # 1, p. 87 - 91
[2] Combinatorial Chemistry and High Throughput Screening, 2013, vol. 16, # 8, p. 618 - 627
[3] Chemical Communications, 2014, vol. 50, # 73, p. 10661 - 10664
[4] Monatshefte fur Chemie, 2007, vol. 138, # 7, p. 663 - 667
[5] Comptes Rendus Chimie, 2013, vol. 16, # 11, p. 1029 - 1034 |
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