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1054315-48-8

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1054315-48-8 Structure

1054315-48-8 Structure
IdentificationBack Directory
[Name]

BMS 695735
[CAS]

1054315-48-8
[Synonyms]

BDBM27888
DNC008930
BMS 695735
CHEMBL459729
BMS 695735 (BMS695735)
VWELCPLMPPEKOL-UHFFFAOYSA-N
2(1H)-Pyridinone, 4-[[2-(4-chloro-1H-pyrazol-1-yl)ethyl]amino]-3-[5-[1-(3-fluoropropyl)-4-piperidinyl]-7-methyl-1H-benzimidazol-2-yl]-
[Molecular Formula]

C26H31ClFN7O
[MDL Number]

MFCD25977743
[MOL File]

1054315-48-8.mol
[Molecular Weight]

512.02
Chemical PropertiesBack Directory
[density ]

1.41±0.1 g/cm3(Predicted)
[pka]

10.44±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

BMS 695735 (compound 10) is an inhibitor of IGF-1R with an IC50 value of 0.034 μM. BMS 695735 has anti-tumor activity[1].
[References]

[1] Discovery and Evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an Orally Efficacious Inhibitor of Insulin-like Growth Factor-1 Receptor Kinase with Broad Spectrum in Vivo Antitumor Activity J. Med. Chem., 2008, 51 (19), pp 5897-5900 DOI:10.1021/jm800832q
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