| Identification | Back Directory | [Name]
N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea | [CAS]
1057249-41-8 | [Synonyms]
CS-901
SNS-314
SNS314;SNS 314
1-(3-chlorophenyl)-3-(4-(2-(thieno[3,2-d]pyriMidin-4-ylaMino)ethyl)thiazol-2-yl)urea
N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea
Urea, N-(3-chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]- | [Molecular Formula]
C18H15ClN6OS2 | [MDL Number]
MFCD16619388 | [MOL File]
1057249-41-8.mol | [Molecular Weight]
430.93 |
| Chemical Properties | Back Directory | [density ]
1.588 | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 100 mg/mL (232.06 mM);Ethanol: Insoluble | [pka]
6.12±0.70(Predicted) | [Water Solubility ]
Water: Insoluble | [InChI]
InChI=1S/C18H15ClN6OS2/c19-11-2-1-3-12(8-11)24-17(26)25-18-21-9-13(28-18)4-6-20-16-15-14(5-7-27-15)22-10-23-16/h1-3,5,7-10H,4,6H2,(H,20,22,23)(H2,21,24,25,26) | [InChIKey]
FAYAUAZLLLJJGH-UHFFFAOYSA-N | [SMILES]
N(C1=CC=CC(Cl)=C1)C(NC1=NC=C(CCNC2N=CN=C3C=CSC3=2)S1)=O |
| Hazard Information | Back Directory | [Uses]
SNS-314 is used in the synthesis of AuroraA kinase inhibitors used in cancer treatment. | [Definition]
ChEBI:1-(3-chlorophenyl)-3-[5-[2-(4-thieno[3,2-d]pyrimidinylamino)ethyl]-2-thiazolyl]urea is a member of ureas. | [in vivo]
In the HCT116 human colon cancer xenograft model, administration of 50 and 100 mg/kg SNS-314 leads to dose-dependent inhibition of histone H3 phosphorylation for at least 10 h. SNS-314 shows significant tumor growth inhibition in a dose dependent manner under a variety of dosing schedules including weekly, bi-weekly, and 5 days on/9 days off[2]. | [IC 50]
Aurora A: 9 nM (IC50); Aurora B: 31 nM (IC50); Aurora C: 6 nM (IC50) | [storage]
Store at -20°C |
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