ChemicalBook--->CAS DataBase List--->1057249-41-8

1057249-41-8

Request For Quotation
1057249-41-8 Structure

1057249-41-8 Structure
IdentificationBack Directory
[Name]

N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea
[CAS]

1057249-41-8
[Synonyms]

CS-901
SNS-314
SNS314;SNS 314
1-(3-chlorophenyl)-3-(4-(2-(thieno[3,2-d]pyriMidin-4-ylaMino)ethyl)thiazol-2-yl)urea
N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea
Urea, N-(3-chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]-
[Molecular Formula]

C18H15ClN6OS2
[MDL Number]

MFCD16619388
[MOL File]

1057249-41-8.mol
[Molecular Weight]

430.93
Chemical PropertiesBack Directory
[density ]

1.588
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 100 mg/mL (232.06 mM);Ethanol: Insoluble
[pka]

6.12±0.70(Predicted)
[Water Solubility ]

Water: Insoluble
[InChI]

InChI=1S/C18H15ClN6OS2/c19-11-2-1-3-12(8-11)24-17(26)25-18-21-9-13(28-18)4-6-20-16-15-14(5-7-27-15)22-10-23-16/h1-3,5,7-10H,4,6H2,(H,20,22,23)(H2,21,24,25,26)
[InChIKey]

FAYAUAZLLLJJGH-UHFFFAOYSA-N
[SMILES]

N(C1=CC=CC(Cl)=C1)C(NC1=NC=C(CCNC2N=CN=C3C=CSC3=2)S1)=O
Hazard InformationBack Directory
[Uses]

SNS-314 is used in the synthesis of AuroraA kinase inhibitors used in cancer treatment.
[Definition]

ChEBI:1-(3-chlorophenyl)-3-[5-[2-(4-thieno[3,2-d]pyrimidinylamino)ethyl]-2-thiazolyl]urea is a member of ureas.
[in vivo]

In the HCT116 human colon cancer xenograft model, administration of 50 and 100 mg/kg SNS-314 leads to dose-dependent inhibition of histone H3 phosphorylation for at least 10 h. SNS-314 shows significant tumor growth inhibition in a dose dependent manner under a variety of dosing schedules including weekly, bi-weekly, and 5 days on/9 days off[2].

[IC 50]

Aurora A: 9 nM (IC50); Aurora B: 31 nM (IC50); Aurora C: 6 nM (IC50)
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea(1057249-41-8)1HNMR
1057249-41-8 suppliers list
Company Name: Shanghai Dongyang Biotechnology Co., Ltd.  Gold
Telephone: 0512-13601744364 13601744364
Website: https://www.chemicalbook.com/ShowSupplierProductsList1201937/0_EN.htm
Company Name: Shanghai Boyle Chemical Co., Ltd.  
Telephone:
Website: www.boylechem.com
Company Name: J & K SCIENTIFIC LTD.  
Telephone: 18210857532 18210857532
Website: https://www.jkchemical.com
Company Name: Chembest Research Laboratories Limited  
Telephone: 021-20908456
Website: www.biochembest.com
Company Name: SYN|thesis med chem P/L  
Telephone: +86-021-50720296
Website: www.synmedchem.cn
Company Name: Guangzhou Isun Pharmaceutical Co., Ltd  
Telephone: 020-39119399 18927568969
Website: http://www.isunpharm.com
Company Name: Jinan Mingya Medical Technology Co., Ltd.  
Telephone: 0531-85828981
Website: www.chemicalbook.com/ShowSupplierProductsList16067/0_EN.htm
Company Name: Credit Asia Chemical Co., Ltd.  
Telephone: +86 (21) 61124340
Website: www.chemicalbook.com/ShowSupplierProductsList16523/0_EN.htm
Company Name: Pharmacodia (Beijing) Co.,Ltd  
Telephone: +86-400-851-9921
Website: www.pharmacodia.com
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Telephone: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Telephone: 18916372613
Website: www.shyuanye.com
Company Name: ShangHai Biochempartner Co.,Ltd  
Telephone: 177-54423994 17754423994
Website: www.biochempartner.com
Company Name: Shanghai Chaolan Chemical Technology Center  
Telephone: QQ：65489617 13301690235
Website: www.atkchemical.com/
Company Name: Amadis Chemical Company Limited  
Telephone: 571-89925085
Website: http://www.amadischem.com
Company Name: Lynnchem  
Telephone: 86-(0)29-85992781 17792393971
Website: http://www.lynnchem.com/
Company Name: Amatek Scientific Co. Ltd.  
Telephone: 0512-56316828 400-867-5858;400-867-5858
Website: http://www.amateksci.com
Company Name: Twochem Co.Ltd.  
Telephone: 021-58111628 15800915896
Website: cn.twochem.com
Company Name: Nanjing crow LuNing pharmaceutical technology co., LTD  
Telephone: 13382066392
Website: www.chemicalbook.com/ShowSupplierProductsList30681/0_EN.htm
Tags:1057249-41-8 Related Product Information
101-54-2 103-70-8 2169919-21-3 212844-53-6 1320288-19-4 1402837-78-8 873436-91-0 1319207-44-7 1432660-47-3 2060571-02-8 968-93-4 1097917-15-1 1227678-26-3 1186222-89-8 345627-90-9 1146618-41-8 345627-80-7 898280-07-4