| Identification | Back Directory | [Name]
MK6-83 | [CAS]
1062271-24-2 | [Synonyms]
MK6-83
spudl 05344
5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide
2-Thiophenesulfonamide, 5-methyl-N-[2-(1-piperidinyl)phenyl]-
MK6-83,fibroblast,lysosome,Mucolipidosis,Transient receptor potential channels,cell,inhibit,MK6 83,TRP Channel,MK-6-83,Inhibitor | [Molecular Formula]
C16H20N2O2S2 | [MDL Number]
MFCD10736412 | [MOL File]
1062271-24-2.mol | [Molecular Weight]
336.47 |
| Chemical Properties | Back Directory | [Melting point ]
115 - 116°C | [Boiling point ]
502.6±60.0 °C(Predicted) | [density ]
1.311±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer, Under inert atmosphere | [solubility ]
Chloroform (Slightly), DMSO (Slightly) | [form ]
Solid | [pka]
8.56±0.50(Predicted) | [color ]
Pale Brown | [InChI]
1S/C16H20N2O2S2/c1-13-9-10-16(21-13)22(19,20)17-14-7-3-4-8-15(14)18-11-5-2-6-12-18/h3-4,7-10,17H,2,5-6,11-12H2,1H3 | [InChIKey]
IRGYSXZCDAWOOC-UHFFFAOYSA-N | [SMILES]
[S](=O)(=O)(Nc2c(cccc2)N3CCCCC3)c1[s]c(cc1)C |
| Hazard Information | Back Directory | [Uses]
MK6-83 is a TRPML channel activator, restoring endolysosomal trafficking and zinc homeostasis lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts. | [Biological Activity]
MK6-83 is a potent activator of wild type and mutant variants F465L and F408D of TRPML1 channel. MK6-83 weakly activates TRPML mutants R403C or V446L. MK6-83 restores channel function and rescue disease associated abnormalities in mucolipidosis type IV (MLIV) patient cells.''MK6-83 is known to stimulate caspase-3-dependent apoptosis. It can also decrease the viability of cells. | [storage]
Store at +4°C |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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