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107348-47-0

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107348-47-0 Structure

107348-47-0 Structure
IdentificationBack Directory
[Name]

N-succinimidyl-3-(2-pyridyldithio)butyrate
[CAS]

107348-47-0
[Synonyms]

PPC-NHS ester
N-succinimidyl-3-(2-pyridyldithio)butyrate
2,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)butanoate
Butanoic acid, 3-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester
[Molecular Formula]

C13H14N2O4S2
[MDL Number]

MFCD28398150
[MOL File]

107348-47-0.mol
[Molecular Weight]

326.39
Chemical PropertiesBack Directory
[solubility ]

Soluble in DMSO
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

PPC-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
[IC 50]

Disulfide Cleavable Linker; Cleavable Linker
[References]

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
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