| Identification | More | [Name]
5-CHLORO-2-METHYLINDOLE | [CAS]
1075-35-0 | [Synonyms]
2-METHYL-5-CHLOROINDOLE
5-CHLORO-2-METHYLINDOLE
RARECHEM AH BS 0087
TIMTEC-BB SBB003903
5-CHLORO-2-METHYLINDOLE 97%
2-Methyl-5-chloro-1H-indole | [EINECS(EC#)]
214-052-9 | [Molecular Formula]
C9H8ClN | [MDL Number]
MFCD00005619 | [Molecular Weight]
165.62 | [MOL File]
1075-35-0.mol |
| Chemical Properties | Back Directory | [Appearance]
light pink to beige-pale brown crystalline powder | [Melting point ]
112-118 °C | [Boiling point ]
140 °C / 0.1mmHg | [density ]
1.1705 (rough estimate) | [refractive index ]
1.5390 (estimate) | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
powder to crystal | [pka]
16.66±0.30(Predicted) | [color ]
White to Gray to Brown | [InChIKey]
WUVWAXJXPRYUME-UHFFFAOYSA-N | [CAS DataBase Reference]
1075-35-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29339980 |
| Hazard Information | Back Directory | [Chemical Properties]
light pink to beige-pale brown crystalline powder | [Uses]
2-Methyl-5-chloroindole has been shown to depress brainstem and telencephalon serotonin for 3 days after 24 hours of being administered intraventricularly.Dyes and metabolites. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 96, p. 5495, 1974 DOI: 10.1021/ja00824a028 | [Synthesis]
In a 100 mL stainless steel autoclave, 1.09 g (5.1 mmol) of 5-chloro-2-nitrophenylacetone and 72 mg (4 mol%) of cyclopentadienyl ferric dicarbonyl (dimer) were added as a catalyst and 40 g of toluene as a solvent, and the system was protected by nitrogen. After displacing the atmosphere in the reactor three times (10 kgf/cm2 nitrogen each time), carbon monoxide gas was injected to a pressure of 30 kgf/cm2. The reaction mixture was stirred at 120 °C for 5 h. The reaction was completed by cooling to room temperature. Upon completion of the reaction, it was cooled to room temperature and the complete conversion of 5-chloro-2-nitrophenylacetone was confirmed by liquid chromatography analysis. Subsequently, the reaction mixture was post-treated and purified by silica gel column chromatographic separation to afford 0.79 g (94.0% yield) of the target product 5-chloro-2-methylindole. | [References]
[1] Patent: US2007/83053, 2007, A1. Location in patent: Page/Page column 7 |
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