| Identification | Back Directory | [Name]
7-Quinolinecarboxylic acid | [CAS]
1078-30-4 | [Synonyms]
AKOS BBS-00005341
7-Carboxyquinoline
quinolin-7-carboxylic acid
7-QUINOLINECARBOXYLIC ACID
QUINOLINE-7-CARBOXYLIC ACID
7-QUINOLINEcarboxylic acid 98%
7-Quinolinecarboxylic acid ,98%
7-Quinolinecarboxylic acid, 95+%
7-Quinolinecarboxylic acid ISO 9001：2015 REACH
7-Carboxyquinoline, 7-Carboxy-1-azanaphthalene | [Molecular Formula]
C10H7NO2 | [MDL Number]
MFCD00047617 | [MOL File]
1078-30-4.mol | [Molecular Weight]
173.17 |
| Chemical Properties | Back Directory | [Melting point ]
249.5°C | [Boiling point ]
303.81°C (rough estimate) | [density ]
1.2427 (rough estimate) | [refractive index ]
1.5200 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
solid | [pka]
2.68±0.30(Predicted) | [color ]
Off-white | [InChI]
InChI=1S/C10H7NO2/c12-10(13)8-4-3-7-2-1-5-11-9(7)6-8/h1-6H,(H,12,13) | [InChIKey]
WXXVQWSDMOAHHV-UHFFFAOYSA-N | [SMILES]
N1C2C(=CC=C(C(O)=O)C=2)C=CC=1 |
| Hazard Information | Back Directory | [Chemical Properties]
Off-white powder | [Uses]
7-Quinolinecarboxylic acid is a reactant used in the chemical & genetic engineering of selective ion channel-ligand interactions. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 68, p. 2721, 1946 DOI: 10.1021/ja01216a093 | [Synthesis]
Step 1: An aqueous solution (50 mL) of lithium hydroxide monohydrate (5.42 g, 141 mmol, 3.0 equiv) was slowly added to a tetrahydrofuran solution (200 mL) of methyl 7-quinolinecarboxylate (8.8 g, 47 mmol). The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the tetrahydrofuran was removed by distillation under reduced pressure. To the remaining aqueous phase, 1N aqueous hydrochloric acid solution (141 mL) was slowly added and the pH was adjusted to 7, at which time a white precipitate was produced. The precipitate was collected by filtration and washed sequentially with water and heptane. The resulting solid was dried in a vacuum oven at 50 °C to give 7-quinolinecarboxylic acid (8.4 g, 100% yield) as a white solid. Liquid chromatography analysis (detection wavelength 215 nm): retention time 0.66 min, purity 100%. Mass spectrum (electrospray positive ion mode): m/z 174 ([M+H]+). 1H NMR (400 MHz, d6-DMSO): δ 9.02 (1H, dd), 8.58 (1H, s), 8.48 (1H, d), 8.09 (2H, m), 7.66 (1H, dd). | [References]
[1] Patent: US2007/60567, 2007, A1. Location in patent: Page/Page column 27 |
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