| Identification | More | [Name]
Malonamide | [CAS]
108-13-4 | [Synonyms]
AURORA KA-4099
CARBOXAMIDOACETAMIDE
CARBOXYACETIC ACID DIAMIDE
DICARBOXYMETHANE DIAMIDE
LABOTEST-BB LT01598526
MALONAMIDE
MALONDIAMIDE
MALONIC ACID AMIDE
MALONIC ACID DIAMIDE
MALONODIAMIDE
METHANEDICARBOXYLIC ACID DIAMIDE
PROPANEDIAMIDE
PROPANEDIOIC ACID DIAMIDE
malonicdiamide
Malonyldiamide
MALONAMIDE, FOR FLUORESCENCE
MALONAMIDE 99+%
Malonamide 98%
MALONAMIDE extrapure
3-Amino-3-oxopropanamide | [EINECS(EC#)]
203-553-8 | [Molecular Formula]
C3H6N2O2 | [MDL Number]
MFCD00008034 | [Molecular Weight]
102.09 | [MOL File]
108-13-4.mol |
| Chemical Properties | Back Directory | [Appearance]
White crystalline powder | [Melting point ]
172-175 °C (lit.) | [Boiling point ]
191.38°C (rough estimate) | [density ]
1.3516 (rough estimate) | [refractive index ]
1.5110 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Soluble in HCl. | [form ]
powder to crystal | [pka]
7.00±0.70(Predicted) | [color ]
White to Almost white | [Water Solubility ]
180 g/L (20 ºC) | [BRN ]
1751401 | [InChI]
InChI=1S/C3H6N2O2/c4-2(6)1-3(5)7/h1H2,(H2,4,6)(H2,5,7) | [InChIKey]
WRIRWRKPLXCTFD-UHFFFAOYSA-N | [SMILES]
C(N)(=O)CC(N)=O | [CAS DataBase Reference]
108-13-4(CAS DataBase Reference) | [NIST Chemistry Reference]
Propanediamide(108-13-4) | [EPA Substance Registry System]
108-13-4(EPA Substance) |
| Safety Data | Back Directory | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
2
| [RTECS ]
ON9125000
| [TSCA ]
Yes | [HS Code ]
29241900 |
| Hazard Information | Back Directory | [Hazard]
Mildly toxic by ingestion. | [Description]
Malonamide is a dicarboxylic acid diamide that is malonic acid in which both carboxy groups have been replaced by carbamoyl groups. It is functionally related to a malonic acid. | [Chemical Properties]
White crystalline powder | [Uses]
Malonamide is a reagent for fluorimetric determination of reducing carbohydrates. The malonamide-based ionic liquid extractant was used in the extraction of europium(iii) and other trivalent rare earth elements from nitric acid medium. | [Uses]
Malonamide is used in the synthesis of malonamic acid, malonamate and malonamide derivative of some heterocyclic compounds with antiinflammatory activity. | [Definition]
ChEBI: Malonamide is a dicarboxylic acid diamide that is malonic acid in which both carboxy groups have been replaced by carbamoyl groups. It is functionally related to a malonic acid. | [General Description]
The malonamide derivatives are obtained by the one-pot, five-component condensation reaction of isocyanide, Meldrum′s acid, arylidene malononitrile, and two amine molecules in CH2Cl2. | [Synthesis]
The synthesis of Malonamide is as follows:
A typical reaction was carried out in a 10 mL flask. Benzonitrile (2 mmol), CuII-4 ? (0.2 g), acetaldoxime (6 mmol) and MeOH (4 mL) were stirred at 65 °C for 4 h. The solid was filtered, washed with MeOH and the filtrate evaporated. The residue was subjected to GC-MS analysis and NMR spectroscopy. The filtered catalyst can be recycled after drying at about 150 °C for 1 h.
 | [Purification Methods]
Crystallise the amide from water. [Beilstein 2 IV 1887.] |
|
|