| Identification | Back Directory | [Name]
4-Quinazolinamine, 6-chloro-2-(4-methyl-1-piperazinyl)-N-(2-thienylmethyl)- | [CAS]
1080623-12-6 | [Synonyms]
VUF10497
VUF-10497
VUF 10497
4-Quinazolinamine, 6-chloro-2-(4-methyl-1-piperazinyl)-N-(2-thienylmethyl)- | [Molecular Formula]
C18H20ClN5S | [MOL File]
1080623-12-6.mol | [Molecular Weight]
373.9 |
| Chemical Properties | Back Directory | [Melting point ]
153.8-155.7 °C | [Boiling point ]
563.5±60.0 °C(Predicted) | [density ]
1.360±0.06 g/cm3(Predicted) | [pka]
9.08±0.59(Predicted) |
| Hazard Information | Back Directory | [Description]
VUF-10497 is a histamine H4 receptor inverse agonist (pKi = 7.57). VUF-10497 also possesses considerable affinity for the human histamine H(1) receptor (H(1)R) and therefore represent a novel class of dual action H(1)R/H(4)R ligands, a profile that potentially leads to added therapeutic benefit. VUF-10497 was found to possess anti-inflammatory properties in vivo in the rat. | [Uses]
VUF10497 is a potent histamine H4 receptor (H4R) inverse agonist with anti-inflammatory activity[1]. | [References]
[1] Smits RA, et al. Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach. J Med Chem. 2008 Dec 25;51(24):7855-65. DOI:10.1021/jm800876b |
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| Company Name: |
Biorbyt Ltd.
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| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
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