1080623-12-6
中文名称
化合物 T24951
英文名称
4-Quinazolinamine, 6-chloro-2-(4-methyl-1-piperazinyl)-N-(2-thienylmethyl)-
CAS
1080623-12-6
分子式
C18H20ClN5S
分子量
373.9
MOL 文件
1080623-12-6.mol

基本信息
中文别名
化合物 T24951 英文别名
VUF10497VUF-10497
VUF 10497
4-Quinazolinamine, 6-chloro-2-(4-methyl-1-piperazinyl)-N-(2-thienylmethyl)-
物理化学性质
熔点153.8-155.7 °C
沸点563.5±60.0 °C(Predicted)
密度1.360±0.06 g/cm3(Predicted)
酸度系数(pKa)9.08±0.59(Predicted)
应用领域
用途一
VUF-10497 is a histamine H4 receptor inverse agonist (pKi = 7.57). VUF-10497 also possesses considerable affinity for the human histamine H(1) receptor (H(1)R) and therefore represent a novel class of dual action H(1)R/H(4)R ligands, a profile that potentially leads to added therapeutic benefit. VUF-10497 was found to possess anti-inflammatory properties in vivo in the rat.