1080623-12-6

中文名称化合物 T24951

英文名称 4-Quinazolinamine, 6-chloro-2-(4-methyl-1-piperazinyl)-N-(2-thienylmethyl)-

CAS 1080623-12-6

分子式 C18H20ClN5S

分子量 373.9

MOL 文件 1080623-12-6.mol

1080623-12-6 结构式

基本信息物理化学性质应用领域

基本信息

中文别名

化合物 T24951

英文别名

VUF10497
VUF-10497
VUF 10497
4-Quinazolinamine, 6-chloro-2-(4-methyl-1-piperazinyl)-N-(2-thienylmethyl)-

物理化学性质

熔点153.8-155.7 °C

沸点563.5±60.0 °C(Predicted)

密度1.360±0.06 g/cm3(Predicted)

酸度系数(pKa)9.08±0.59(Predicted)

应用领域

用途一

VUF-10497 is a histamine H4 receptor inverse agonist (pKi = 7.57). VUF-10497 also possesses considerable affinity for the human histamine H(1) receptor (H(1)R) and therefore represent a novel class of dual action H(1)R/H(4)R ligands, a profile that potentially leads to added therapeutic benefit. VUF-10497 was found to possess anti-inflammatory properties in vivo in the rat.