| Identification | Back Directory | [Name]
KX2-391 (Mesylate) | [CAS]
1080645-95-9 | [Synonyms]
KX01 MESYLATE
KX2-391 (Mesylate)
Tirbanibulin Mesylate
2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide mesylate
KX01,KX2-391,Src,Tirbanibulin Mesylate,Inhibitor,inhibit,KX-01,Tirbanibulin,KX 01,Microtubule/Tubulin | [Molecular Formula]
C27H33N3O6S | [MDL Number]
MFCD30496706 | [MOL File]
1080645-95-9.mol | [Molecular Weight]
527.632 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C, protect from light, stored under nitrogen | [solubility ]
DMSO : ≥ 57 mg/mL (108.03 mM) | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Tirbanibulin Mesylate (KX2-391 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. | [in vivo]
Orally administered Tirbanibulin Mesylate (KX2-391 Mesylate) is shown to inhibit primary tumor growth and to suppress metastasis, in pre-clinical animal models of cancer[2]. | [References]
[1] Lau GM, et al. Expression of Src and FAK in hepatocellular carcinoma and the effect of Src inhibitors on hepatocellular carcinoma in vitro. Dig Dis Sci, 2009, 54(7), 1465-1474. DOI:10.1007/s10620-008-0519-0
[2] Fallah-Tafti A, et al. Thiazolyl N-benzyl-substituted acetamide derivatives: synthesis, Src kinase inhibitory and anticancer activities. Eur J Med Chem, 2011, 46(10), 4853-4858. DOI:10.1016/j.ejmech.2011.07.050 |
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Musechem
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+1-800-259-7612 |
| Website: |
www.musechem.com |
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Twochem Co.Ltd.
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021-58111628 15800915896 |
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cn.twochem.com |
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InvivoChem
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13549236410 |
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https://www.invivochem.cn/ |
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