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Carbazomycin C (compound III) is a minor component of the carbazomycin complex with antibacterial activity, and its structure has been determined by spectroscopic and chemical methods to be 4-hydroxy-3,6-dimethyl-1,2-dimethylcarbazole. | [Biological Activity]
Carbazomycin C is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities.1,2,3 It is active against S. aureus, B. anthracis, B. subtilis, and M. flavus (MICs = 50, 25, 100, and 50 μg/ml, respectively), the fungi T. asteroides and T. mentagrophytes (MICs = 25 and 100 μg/ml, respectively), and P. falciparum (IC50 = 2.1 μg/ml).2 It is also active against a panel of five plant pathogenic fungi (MICs = 12.5-100 μg/ml).1 Carbazomycin C is cytotoxic to MCF-7, KB, and NCI H187 cells (IC50s = 9.8, 21.4, and 8.2 μg/ml, respectively).2 It also inhibits 5-lipoxygenase (5-LO) activity in RBL-1 cell extracts (IC50 = 1.9 μM).3 | [storage]
-20°C | [References]
1.Naid, T., Kitahara, T., Kaneda, M., et al.Carbazomycins C, D, E and F, minor components of the carbazomycin complexJ. Antibiot. (Tokyo)40(2)157-164(1987)
2.Intaraudom, C., Rachtawee, P., Suvannakad, R., et al.Antimalarial and antituberculosis substances from Streptomyces sp. BCC26924Tetrahedron67(39)7593-7597(2011)
3.Hook, D.J., Yacobucci, J.J., O'Connor, S., et al.Identification of the inhibitory activity of carbazomycins B and C against 5-lipoxygenase, a new activity for these compoundsJ. Antibiot. (Tokyo)43(10)1347-1348(1990)
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