| Identification | More | [Name]
LUMICHROME | [CAS]
1086-80-2 | [Synonyms]
7,8-DIMETHYLALLOXAZINE
LUMICHROME
7,8-Dimethylbenzo[g]pteridine-2,4-diol
Benzo[g]pteridine-2,4(1H,3H)-dione, 7,8-dimethyl-
Lumichrome (I)
Riboflavin lumichrome
7,8-dimethylbenzo[g]pteridine-2,4(1H,3H)-dione
7,8-Dimethylbenzo[g]pteridine-2,4(3H,10H)-dione
7,8-Dimethylpyrimido[4,5-b]quinoxaline-2,4(3H,10H)-dione | [EINECS(EC#)]
214-120-8 | [Molecular Formula]
C12H10N4O2 | [MDL Number]
MFCD00005021 | [Molecular Weight]
242.23 | [MOL File]
1086-80-2.mol |
| Chemical Properties | Back Directory | [Appearance]
solid | [Melting point ]
300 °C | [Boiling point ]
385.06°C (rough estimate) | [density ]
1.2532 (rough estimate) | [refractive index ]
1.6081 (estimate) | [storage temp. ]
Refrigerator | [solubility ]
Aqueous Base (Slightly), DMSO (Slightly, Heated, Sonicated) | [form ]
Solid | [pka]
10.02±0.70(Predicted) | [color ]
Pale Yellow to Yellow | [Stability:]
Stable. Incompatible with strong oxidizing agents. Combustible. | [λmax]
350 nm
392 nm (2nd) | [Merck ]
13,5620 | [Major Application]
diagnostic assay manufacturing
hematology
histology | [InChI]
1S/C12H10N4O2/c1-5-3-7-8(4-6(5)2)14-10-9(13-7)11(17)16-12(18)15-10/h3-4H,1-2H3,(H2,14,15,16,17,18) | [InChIKey]
ZJTJUVIJVLLGSP-UHFFFAOYSA-N | [SMILES]
Cc1cc2nc3NC(=O)NC(=O)c3nc2cc1C | [CAS DataBase Reference]
1086-80-2(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Uses]
Lumichrome is a derivative of Riboflavin, a vitamin with a key role in maintaining cellular function and health in human and animals. Dyes and metabolites. |
| Safety Data | Back Directory | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3 | [HS Code ]
2933.99.8210 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
solid | [Definition]
ChEBI: A compound showing blue fluorescence, formed by a photolysis of riboflavin in acid or neutral solution. | [in vivo]
Lumichrome (7.5 mg/kg, ip, three times a week for 6 weeks) reduces bone loss and prevents osteoporosis in the ovariectomized (OVX) mouse model[3]. | Animal Model: | OVX mouse model[3] | | Dosage: | 7.5 mg/kg | | Administration: | ip, three times a week for 6 weeks | | Result: | Increased bone mineral density (BMD) and bone volume fraction (BV/TV) in OVX mice, and reduced the osteoclast surface/bone surface (Oc.S/BS) ratio. |
| [storage]
Store at -20°C | [Purification Methods]
Recrystallise lumichrome twice from glacial AcOH and dry it at 100o in a vacuum. [Cresswell & Wood J Chem Soc 4768 1960, Beilstein 26 III/IV 2538.] |
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