| Identification | Back Directory | [Name]
Methyl 3-bromoindazole-5-carboxylate | [CAS]
1086391-06-1 | [Synonyms]
Methyl 3-bromoindazole-5-...
Methyl 3-broMoindazol-5-carboxylate
Methyl 3-bromoindazole-5-carboxylate
methyl 3-bromo-2H-indazole-5-carboxylate
Methyl 3-BroMo-1H-indazole-5-carboxylate
3-BROMO-1H-INDAZOLE-5-CARBOXYLIC ACID METHYL ESTER
3-bromo-2H-indazole-4-carboxylic acid methyl ester
1H-Indazole-5-carboxylic acid, 3-bromo-, methyl ester | [Molecular Formula]
C9H7BrN2O2 | [MDL Number]
MFCD11045401 | [MOL File]
1086391-06-1.mol | [Molecular Weight]
255.07 |
| Chemical Properties | Back Directory | [Boiling point ]
399.7±22.0 °C(Predicted) | [density ]
1.709 | [storage temp. ]
Store at room temperature | [pka]
10.62±0.40(Predicted) | [Appearance]
White to yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of methyl 3-bromo-1H-indazole-5-carboxylate from methyl 1H-indazole-5-carboxylate: a mixture of methyl 1H-indazole-5-carboxylate (1.7 g, 0.01 mol) with N-bromosuccinimide (NBS, 2.1 g, 0.012 mol) in tetrahydrofuran (THF, 10 ml) was stirred at room temperature overnight. After completion of the reaction, the mixture was concentrated to give a residue. To the residue was added dichloromethane (DCM, 5 ml), stirred for 30 min and filtered to give methyl 3-bromo-1H-indazole-5-carboxylate (1.9 g, 80% yield) as a light yellow solid. | [References]
[1] Patent: US2014/128391, 2014, A1. Location in patent: Paragraph 0392; 0393; 0394
[2] Patent: WO2013/78237, 2013, A1. Location in patent: Page/Page column 54 |
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