| Identification | Back Directory | [Name]
1H-Indole-4-carboxylic acid, 5-chloro-3-pyridinyl ester | [CAS]
1087243-14-8 | [Synonyms]
GRL-0496
1H-Indole-4-carboxylic acid, 5-chloro-3-pyridinyl ester
chloropyridyl,GRL-0496,3CLpro,inhibit,GRL0496,Inhibitor,SARS-CoV,GRL 0496,SARS coronavirus | [Molecular Formula]
C14H9ClN2O2 | [MDL Number]
MFCD34471049 | [MOL File]
1087243-14-8.mol | [Molecular Weight]
272.69 |
| Chemical Properties | Back Directory | [Boiling point ]
483.9±35.0 °C(Predicted) | [density ]
1.431±0.06 g/cm3(Predicted) | [storage temp. ]
-20° | [solubility ]
Soluble in DMSO (>30 mg/mL) and ethanol (>25 mg/mL) | [form ]
solid | [pka]
15.35±0.30(Predicted) | [color ]
White | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| Hazard Information | Back Directory | [Description]
GRL-0496 (1087243-14-8) is a potent (IC50?= 30 nM in cell culture assays) inhibitor of severe acute respiratory syndrome-coronavirus chymotrypsin-like protease (SARS-CoV 3CLpro).1 | [Uses]
GRL-0496 is a potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitor, with an IC50 of 30 nM in both enzyme inhibitory and antiviral assays. GRL-0496 shows SARS-CoV antiviral activity, with an EC50 of 6.9 μM[1]. | [Definition]
ChEBI: (5-Chloropyridin-3-yl) 1H-indole-4-carboxylate is an indolyl carboxylic acid. It has a role as an anticoronaviral agent. | [storage]
Store at -20°C | [References]
1)????Ghosh?et al. (2008),?Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors;?Bioorg. Med. Chem.Lett,?18?5684 |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|