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Nurr1 agonist 11 (compound 53) is a selective and potent Nurr1 agonist with an IC50 of 26 μM. Nurr1 agonist 11 has the ability to cross a cellular model of the blood-brain-barrier (BBB) [1]. | [References]
[1] Willems S, et al. Structural Optimization of Oxaprozin for Selective Inverse Nurr1 Agonism. J Med Chem. 2024 Aug 8;67(15):13324-13348. DOI:10.1021/acs.jmedchem.4c01218 |
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