| Identification | Back Directory | [Name]
Crebinostat | [CAS]
1092061-61-4 | [Synonyms]
CREBINOSTAT
CRBT crebinostat
CRBT,CREBINOSTAT
Heptanoic acid, 7-(hydroxyamino)-7-oxo-, 2-([1,1'-biphenyl]-4-ylmethylene)hydrazide | [Molecular Formula]
C20H23N3O3 | [MDL Number]
MFCD34184472 | [MOL File]
1092061-61-4.mol | [Molecular Weight]
353.41 |
| Hazard Information | Back Directory | [Uses]
Crebinostat is a small molecular inhibitor of histone deacetylases (HDACs). it also modulates chromatin-mediated neuroplasticity. | [Definition]
ChEBI: N'-hydroxy-N-[(4-phenylphenyl)methylideneamino]heptanediamide is a member of biphenyls. | [in vivo]
Crebinostat (25 mg/kg; IP; for 10 days) enhances memory of contextual fear conditioning in mice; induces an increase in total hippocampal acetylation of H4K12 and H3K9[1]. | Animal Model: | Male C57BL/6J mice (9-10 weeks)[1] | | Dosage: | 25 mg/kg | | Administration: | IP; alternate daily between left and right sides of the abdomen, for 10 days | | Result: | Enhanced memory of contextual fear conditioning in mice; induced a trend towards an increase in total hippocampal acetylation of both H4K12 and H3K9. |
| [IC 50]
HDAC1: 0.7 nM (IC50); HDAC2: 1.0 nM (IC50); HDAC3: 2.0 nM (IC50); HDAC6: 9.3 nM (IC50) |
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DoCheman Shanghai Co., Ltd.
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+86-21-31664694 157 21077413 |
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| Company Name: |
InvivoChem
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13549236410 |
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https://www.invivochem.cn/ |
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