| Identification | Back Directory | [Name]
H-ASP-D-PRO-HIS-ASP-PHE-D-TRP-VAL-D-TRP-LEU-NLE-NH2 | [CAS]
109212-72-8 | [Synonyms]
(D-Pro2,D-Trp6
DPHDFWVWL-NLE-NH2
(D-PRO2,D-TRP6,8,NLE10)-NEUROKININ B
ASP-D-PRO-HIS-ASP-PHE-D-TRP-VAL-D-TRP-LEU-NLE-NH2
H-ASP-D-PRO-HIS-ASP-PHE-D-TRP-VAL-D-TRP-LEU-NLE-NH2
L-Norleucinamide,L-α-aspartyl-D-prolyl-L-histidyl-L-α-aspartyl-L-phenylalanyl-D-tryptophyl-L-valyl-D-tryptophyl-L-leucyl-
L-Norleucinamide, L-α-aspartyl-D-prolyl-L-histidyl-L-α-aspartyl-L-phenylalanyl-D-tryptophyl-L-valyl-D-tryptophyl-L-leucyl- (9CI) | [Molecular Formula]
C67H87N15O14 | [MDL Number]
MFCD00167606 | [MOL File]
109212-72-8.mol | [Molecular Weight]
1326.5 |
| Hazard Information | Back Directory | [Uses]
(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B is a competitive antagonist of Neurokinin B (Neurokinin Receptor) with a pA2 of 5.5. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B shows no influence on Substance P or Neurokinin A[1]. | [in vivo]
(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B (1 mg/kg i.v.) significantly reduces Substance P- and Neurokinin B- but not acetylcholine- or Neurokinin A-induced salivation. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B lowers blood pressure in anesthetized rats by 35 to 40%[2]. | [References]
[1] H I Jacoby, et al. Differentiation of multiple neurokinin receptors in the guinea pig ileum. Life Sci. 1986 Nov 24;39(21):1995-2003. DOI:10.1016/0024-3205(86)90323-1
[2] C W Murray, et al. Neurokinin-induced salivation in the anesthetized rat: a three receptor hypothesis. J Pharmacol Exp Ther. 1987 Aug;242(2):500-6. DOI:10.1016/0024-3205(86)90323-1 |
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