| Identification | Back Directory | [Name]
3-((3R,4S)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanenitrile | [CAS]
1092578-46-5 | [Synonyms]
Tofacitinib-14
(3R,4S)-Tofacitinib
Tofacitib impurity A
Tofacitinib IMpurity E
RS-tofacitinib citirate
Tofacitinib Impurity A(3R,4S)
Azilsartan medoxomil impurity340
Tofacitinib Impurity A (3R,4S)-Tofacitinib
(3R,4S)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrile
(3R,4S)-4-Methyl-3-(Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMino)-beta-oxo-1-piperidinepropanenitrile
1-Piperidinepropanenitrile, 4-Methyl-3-(Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMino)-β-oxo-, (3R,4S)-
3-((3R,4S)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanenitrile
Tofacitinib impurity 10/(3R,4S)-Tofacitinib/3-((3R,4S)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino) piperidin-1-yl)-3-oxopropanenitrile | [Molecular Formula]
C16H20N6O | [MDL Number]
MFCD23160057 | [MOL File]
1092578-46-5.mol | [Molecular Weight]
312.37 |
| Chemical Properties | Back Directory | [Melting point ]
>108°C (dec.) | [density ]
1.296 | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
6.04±0.60(Predicted) | [color ]
Pale Yellow to Yellow | [InChI]
InChI=1/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13-/s3 | [InChIKey]
UJLAWZDWDVHWOW-PZILLZCRNA-N | [SMILES]
C(#N)CC(N1CC[C@H](C)[C@@H](N(C)C2=NC=NC3NC=CC=32)C1)=O |&1:7,9,r| |
| Hazard Information | Back Directory | [Uses]
(3R,4S)-Tofacitinib is an enantiopure stereoisomer of the drug, Janus kinase 3(Jak3) inhibitor (CP-690,550) that has been found to inhibit selected members of the STE7 and STE20 subfamily of kinases. | [Definition]
ChEBI: (3r,4s)-Tofacitinib is a N-acylpiperidine. |
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