| Identification | Back Directory | [Name]
N-[5-(4-Cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-3-pyridinecarboxamide | [CAS]
1093222-27-5 | [Synonyms]
CS-2864
MDK-2275
Pim1/AKK1-IN-1
3-b]pyridin-3-yl]-
AAK1 dual inhibitor
Pim1/AKK1 inhibitor 1
LKB1(AAK1 dual inhibitor)
N-[5-(4-cyanophenyl)-1H-pyrrolo[2
LKB1/AAK1 DUAL INHIBITOR;AAK1 DUAL INHIBITOR
N-[5-(4-Cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-3-pyridinecarboxamide
3-PyridinecarboxaMide, N-[5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-
LKB1/AAK1 DUAL INHIBITOR;3-PYRIDINECARBOXAMIDE; N-[5-(4-CYANOPHENYL)-1H-PYRROLO[2;3-B]PYRIDIN-3-YL]- | [Molecular Formula]
C20H13N5O | [MOL File]
1093222-27-5.mol | [Molecular Weight]
339.35 |
| Chemical Properties | Back Directory | [density ]
1.42 | [storage temp. ]
Store at -20°C | [solubility ]
insoluble in EtOH; insoluble in H2O; ≥34.8 mg/mL in DMSO | [form ]
Powder | [pka]
11.62±0.43(Predicted) | [color ]
White to gray |
| Hazard Information | Back Directory | [Uses]
Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK. | [IC 50]
PIM1 | [storage]
Store at -20°C | [References]
[1] Bamborough P, et al. Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. J Med Chem. 2008 Dec 25;51(24):7898-914. DOI:10.1021/jm8011036 |
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