| Identification | Back Directory | [Name]
Ethanesulfonamide, N-[(3aR,4R,5R,7R,7aS)-2-[4-cyano-3-(trifluoromethyl)phenyl]octahydro-4,7-dimethyl-1,3-dioxo-4,7-epoxy-1H-isoindol-5-yl]- | [CAS]
1093276-09-5 | [Synonyms]
Ethanesulfonamide, N-[(3aR,4R,5R,7R,7aS)-2-[4-cyano-3-(trifluoromethyl)phenyl]octahydro-4,7-dimethyl-1,3-dioxo-4,7-epoxy-1H-isoindol-5-yl]- | [Molecular Formula]
C20H20F3N3O5S | [MOL File]
1093276-09-5.mol | [Molecular Weight]
471.45 |
| Chemical Properties | Back Directory | [Boiling point ]
678.9±65.0 °C(Predicted) | [density ]
1.53±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
10.06±0.60(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
BMS-641988 (compound 23) is an oral active nonsteroidal androgen receptor antagonist with the Ki of 1.7 nM. BMS-641988 shows anticancer activity[1]. | [Definition]
ChEBI: N-[(3aR,4R,5R,7R,7aS)-2-[4-cyano-3-(trifluoromethyl)phenyl]-4,7-dimethyl-1,3-dioxo-3a,5,6,7a-tetrahydro-octahydro-1H-4,7-epoxyisoindol-5-yl]ethanesulfonamide is an organonitrogen compound and an organooxygen compound. It is functionally related to a delta-amino acid. | [References]
[1] Balog A, et al. Discovery of BMS-641988, a Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer. ACS Med Chem Lett. 2015;6(8):908-912. Published 2015 Jun 19. DOI:10.1021/acsmedchemlett.5b00173 |
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