| Identification | Back Directory | [Name]
Urea, N-[4-[4-aMino-1-(1-Methylethyl)-1H-pyrazolo[3,4-d]pyriMidin-3-yl]phenyl]-N'-[3-(trifluoroMethyl)phenyl]- | [CAS]
1093380-42-7 | [Synonyms]
AD57
1-[4-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]urea
Urea, N-[4-[4-aMino-1-(1-Methylethyl)-1H-pyrazolo[3,4-d]pyriMidin-3-yl]phenyl]-N'-[3-(trifluoroMethyl)phenyl]- | [Molecular Formula]
C22H20F3N7O | [MOL File]
1093380-42-7.mol | [Molecular Weight]
455.44 |
| Hazard Information | Back Directory | [Uses]
AD57 is an orally active multikinase inhibitor, inhibits RET, BRAF, S6K and Src, with greatly reduces mTOR activity[1]. | [in vivo]
AD57 inhibits the viability of MEN2B (MZ-CRC-1) and MEN2A (TT) patient-derived cell lines in RETMEN2 models[1].
AD57 (20 mg/kg) significantly inhibits TT-based tumour growth without obvious cytotoxicity in conventional mouse xenograft model[1]. | [IC 50]
Braf | [References]
[1] Dar AC, et al. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature. 2012 Jun 6;486(7401):80-4. DOI:10.1038/nature11127 |
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BOC Sciences
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1-631-485-4226; 16314854226 |
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https://www.bocsci.com |
| Company Name: |
SPIRO PHARMA
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www.spiropharma.com.cn |
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