| Identification | Back Directory | [Name]
I-OME-AG 538 | [CAS]
1094048-77-7 | [Synonyms]
I-OME-AG 538
I-OME-TYRPHOSTIN AG 538
TYRPHOSTIN I-OME-AG 538
α-Cyano-(3-methoxy-4-hydroxy-5-iodocinnamoyl)-(3′,4′-dihydroxyphenyl)ketone
ALPHA-CYANO-(3-METHOXY-4-HYDROXY-5-IODOCINNAMOYL)-(3',4'-DIHYDROXYPHENYL)KETONE
I-OMe-AG 538, α-Cyano-(3-methoxy-4-hydroxy-5-iodocinnamoyl)-(3μ,4μ-dihydroxyphenyl)ketone | [Molecular Formula]
C17H12INO5 | [MDL Number]
MFCD03453582 | [MOL File]
1094048-77-7.mol | [Molecular Weight]
437.19 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMSO : 50 mg/mL (114.37 mM; Need ultrasonic) | [form ]
solid
| [color ]
Yellow to orange | [InChI]
1S/C17H12INO5/c1-24-15-6-9(5-12(18)17(15)23)4-11(8-19)16(22)10-2-3-13(20)14(21)7-10/h2-7,20-21,23H,1H3/b11-4+ | [InChIKey]
HSRMHXWCTRFVHK-NYYWCZLTSA-N | [SMILES]
COc1cc(cc(I)c1O)\C=C(/C#N)C(=O)c2ccc(O)c(O)c2 |
| Hazard Information | Back Directory | [Uses]
I-OMe-Tyrphostin AG 538 has been used as a cell signaling inhibitor in PC-1 cell lines. It has also been used in high throughput screening assays for IGF1R inhibitors. | [Definition]
ChEBI: 2-[(3,4-dihydroxyphenyl)-oxomethyl]-3-(4-hydroxy-3-iodo-5-methoxyphenyl)-2-propenenitrile is a member of chalcones. | [Biochem/physiol Actions]
Insulin growth factor 1 (IGF-1) receptor protein tyrosine kinase inhibitor. |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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