| Identification | Back Directory | [Name]
CIS-4-[PHOSPHONOMETHYL]-PIPERIDINE-2-CARBOXYLIC ACID | [CAS]
110347-85-8 | [Synonyms]
Selfotel
CGS 19755
LY-272541
CPDD 0027
CGS-19755 \ POTENT COMPETITIVE NMDA RECE
4-(phosphonomethyl)-2-piperidinecarboxylic acid
cis-4-[Phosphomethyl]-piperidine-2-carboxylicacid
CIS-4-[PHOSPHONOMETHYL]-PIPERIDINE-2-CARBOXYLIC ACID
(2S,4R)-4-(phosphonomethyl)piperidine-2-carboxylic acid
CIS-(2S,4R)-4-(phosphonomethyl)piperidine-2-carboxylic acid
2-Piperidinecarboxylic acid, 4-(phosphonomethyl)-, (2R,4S)-rel- | [Molecular Formula]
C7H14NO5P | [MDL Number]
MFCD06795863 | [MOL File]
110347-85-8.mol | [Molecular Weight]
223.16 |
| Chemical Properties | Back Directory | [Melting point ]
290-292 °C | [Boiling point ]
508.6±60.0 °C(Predicted) | [density ]
1.440±0.06 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
H2O: soluble | [form ]
solid | [pka]
2.29±0.10(Predicted) | [color ]
white | [Water Solubility ]
Soluble to 25 mM in water |
| Hazard Information | Back Directory | [Uses]
CGS 19755 is a potent and competitive NMDA antagonist. | [Uses]
NMDA antagonist. | [Definition]
ChEBI: Selfotel is a non-proteinogenic alpha-amino acid. | [Biological Activity]
Potent, competitive NMDA receptor antagonist. Anticonvulsant and neuroprotective. Also available as part of the Mixed NMDA Receptor Tocriset™ . | [in vivo]
Selfotel (CGS 19755) administered p.o. by gavage has little or no effect in these test procedures. In an experimental model of anxiety in rats[1].
Selfotel (CGS 19755) significantly increases conflict responding within a relatively narrow dose range (minimum effective dose, 1.73 mg/kg i.p.)[1].
Selfotel (CGS 19755) blocks the harmaline-induced increase in cerebellar cyclic GMP levels at a dose of 4 mg/kg i.p. with duration of action exceeding 2 hr[2].
Selfotel (CGS 19755) inhibits convulsions elicited by maximal electroshock in rat (ED50 = 3.8 mg/kg i.p. 1 hr after administration) and in mouse (ED50 = 2.0 mg/kg i.p. 0.5 hr after administration)[2].
| [storage]
Store at RT |
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