| Identification | Back Directory | [Name]
PARA-TOPOLIN RIBOSIDE 99% (HPLC) | [CAS]
110505-75-4 | [Synonyms]
NHBA (T1-11)
PARA-TOPOLIN RIBOSIDE
N6-(4-Hydroxybenzyl)adenosine
PARA-TOPOLIN RIBOSIDE 99% (HPLC)
N-[(4-Hydroxyphenyl)methyl]adenosine
N6-(4-Hydroxybenzyl)adenosine (NHBA)
Adenosine, N-[(4-hydroxyphenyl)methyl]-
N6-(4-Hydroxybenzyl) adenine riboside >=98% (HPLC)
N6-(4-Hydroxybenzyl)adenosine (Para-topolin riboside)
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[(4-hydroxyphenyl)methylamino]purin-9-yl]oxolane-3,4-diol | [Molecular Formula]
C17H19N5O5 | [MDL Number]
MFCD18641957 | [MOL File]
110505-75-4.mol | [Molecular Weight]
373.36 |
| Chemical Properties | Back Directory | [Melting point ]
201-204 °C(Solv: methanol (67-56-1); chloroform (67-66-3)) | [Boiling point ]
753.2±70.0 °C(Predicted) | [density ]
1.71 | [storage temp. ]
Hygroscopic, Refrigerator, under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly, Sonicated) | [form ]
Solid | [pka]
9.72±0.15(Predicted) | [color ]
White to Off-White | [InChIKey]
UGVIXKXYLBAZND-LSCFUAHRSA-N | [SMILES]
OC[C@H]1O[C@@H](N2C=NC3=C2N=CN=C3NCC4=CC=C(O)C=C4)[C@H](O)[C@@H]1O |
| Hazard Information | Back Directory | [Uses]
N6-(4-Hydroxybenzyl)adenosine is am endogenous compound extracted from G. elata for research interest for its potential sedative and hypnotic activity, as well as a neuroprotective and therapeutic agent for preventing and treating neurodegenerative disease. | [Biological Activity]
N6-(4-Hydroxybenzyl) adenine riboside (NHBA) is an orally available and brain penetrant active active ingredient of Gastrodia elata rhizomes used for the treatment of insomnia. N6-(4-Hydroxybenzyl) adenine riboside is an adenosine A2A receptor and the equilibrative nucleoside transporter 1 (ENT1) agonist. It exhibits sedative and hypnotic effects by binding to adenosine A1 and A2A receptors in mice. N6-(4-Hydroxybenzyl) adenine riboside exerted a therapeutic effect on HD transgenic mouse by decreasing protein level of polyglutamine-expanded huntingtin in the striatum. |
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| Company Name: |
NewCan Biotech Limited
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| Telephone: |
+86-571-86912261 19975279805 |
| Website: |
https://www.newcanbio.com/ |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Bide Pharmatech Ltd.
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| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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