| Identification | Back Directory | [Name]
phelorphan | [CAS]
110871-16-4 | [Synonyms]
phelorphan
Mercaptoacetyl-L-Phe-L-Phe-OH
N-[N-(Mercaptoacetyl)-L-phenylalanyl]-L-phenylalanine
L-Phenylalanine, mercaptoacetyl-L-phenylalanyl- (9CI) | [Molecular Formula]
C20H22N2O4S | [MOL File]
110871-16-4.mol | [Molecular Weight]
386.46 |
| Hazard Information | Back Directory | [Description]
Phelorphan is an enkephalinase inhibitor. | [Uses]
Phelorphan is a purine MTH1 inhibitor identified through chemical array screening. Although it targets cellular MTH1, its cytotoxicity to cancer cells is weaker than that of other reported inhibitors. The cytotoxicity of MTH1 inhibitors may be attributed to off-target effects, and MTH1 is not essential for cancer cell survival. | [References]
[1] Synthesis of enkephalinase B inhibitors, and their activity on isolated enkephalin-degrading enzymes |
|
|