| Identification | Back Directory | [Name]
2-Pyrrolidinecarboxamide, 1-[3-cyano-6-methyl-4-(trifluoromethyl)-2-pyridinyl]-3-hydroxy-N-methyl-N-(3-methylphenyl)-, (2S,3R)- | [CAS]
2603528-97-6 | [Synonyms]
ART558
(2S,3R)-1-(3-Cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl)-3-hydroxy-N-methyl-N-(m-tolyl)pyrrolidine-2-carboxamide
2-Pyrrolidinecarboxamide, 1-[3-cyano-6-methyl-4-(trifluoromethyl)-2-pyridinyl]-3-hydroxy-N-methyl-N-(3-methylphenyl)-, (2S,3R)- | [Molecular Formula]
C21H21F3N4O2 | [MDL Number]
MFCD34474085 | [MOL File]
2603528-97-6.mol | [Molecular Weight]
418.41 |
| Chemical Properties | Back Directory | [Boiling point ]
621.9±55.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [solubility ]
DMSO: Soluble: =10 mg/ml
Ethanol: Sparingly Soluble: 1-10 mg/ml | [form ]
Solid | [pka]
13.58±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ART558 is a nanomolar potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM). ART558 can be used for the research of cancer[1]. | [References]
[1] Zatreanu D, et al. Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance. Nat Commun. 2021 Jun 17;12(1):3636. DOI:10.1038/s41467-021-23463-8 |
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