| Identification | Back Directory | [Name]
1H-Thieno(3,4-d)imidazole, 2-(((5-methyl-2-pyridinyl)methyl)sulfinyl)- | [CAS]
111371-30-3 | [Synonyms]
S 1924
2-[[(5-Methyl-2-pyridinyl)methyl]sulfinyl]-1H-thieno[3,4-d]imidazole
1H-Thieno(3,4-d)imidazole, 2-(((5-methyl-2-pyridinyl)methyl)sulfinyl)- | [Molecular Formula]
C12H11N3OS2 | [MOL File]
111371-30-3.mol | [Molecular Weight]
277.37 |
| Hazard Information | Back Directory | [Description]
S 1924 is a member of a new class of H+, K+-ATPase inhibitors. | [Uses]
S 1924 is a potent H+, K+-ATPase inhibitor, with IC50 values of 10.3 and 1.6 μM at pH 7.4 and pH 6.0, respectively[1]. | [in vivo]
S 1924 (0.5 mg/kg, iv) inhibits desglugastrin (100 μg/kg/h, iv)-stimulated gastric acid secretion in stomach-lumen-perfused rats[1]. | [References]
[1] Herling AW, et al. A substituted thieno[3.4-d]imidazole versus substituted benzimidazoles as H+, K+-ATPase inhibitors. Pharmacology. 1988;36(5):289-97. DOI:10.1159/000138397 |
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