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1116085-98-3

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1116085-98-3 Structure

1116085-98-3 Structure
IdentificationBack Directory
[Name]

L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanyl-N-[4-(hydroxymethyl)phenyl]-N6-(triphenylmethyl)-
[CAS]

1116085-98-3
[Synonyms]

Fmoc-Phe-Lys(Trt)-PAB
L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanyl-N-[4-(hydroxymethyl)phenyl]-N6-(triphenylmethyl)-
L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanyl-N-[4-(hydroxymethyl)phenyl]-N6-(triphenylmethyl)- USP/EP/BP
[Molecular Formula]

C56H54N4O5
[MDL Number]

MFCD34180563
[MOL File]

1116085-98-3.mol
[Molecular Weight]

863.05
Chemical PropertiesBack Directory
[Boiling point ]

1058.4±65.0 °C(Predicted)
[density ]

1.229±0.06 g/cm3(Predicted)
[pka]

10.67±0.46(Predicted)
Hazard InformationBack Directory
[Uses]

Fmoc-Phe-Lys(Trt)-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
[Biological Activity]

Fmoc-Phe-Lys(Trt)-PAB is a cleavable ADC linker that can be used to synthesize antibody drug conjugates (ADCs).
[in vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[target]

Cleavable

[IC 50]

Protease Cleavable Linker; Cleavable Linker
[References]

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
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