| Identification | Back Directory | [Name]
BOC-GLYCINE TERT-BUTYL ESTER | [CAS]
111652-20-1 | [Synonyms]
N-Boc-gL
BOC-GLY-OTBU
N-BOC-Gly-OtBu
Boc-Gly-OtBu, ≥98%
Boc-Gly-OtBu
BOC-GLYCINE T-BUTYL ESTER
BOC-GLYCINE TERT-BUTYL ESTER
(Tert-Butoxy)Carbonyl Gly-OtBu
N-Boc-glycine tert-butyl ester, 95%
BOC-GLYCINE TERT-BUTYL ESTER USP/EP/BP
Boc-glycinetert-butyl ester≥ 98% (HPLC)
tert-butyl 2-(tert-butoxycarbonyl)acetate
Tert butyloxycarbonylglycine tert butyl ester
N-(TERT-BUTOXYCARBONYL)GLYCINE TERT-BUTYL ESTER
N-alpha-t-Butyloxycarbonyl-glycine t-butyl ester
tert-Butyl 2-((tert-butoxycarbonyl)aMino)acetate
N-(tert-Butoxycarbonyl)glycine tert-Butyl Ester >
(tert-Butoxycarbonylamino)acetic acid tert-butyl ester
ert-butyl2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate
tert-butyl 2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate
Glycine, N-[(1,1-diMethylethoxy)carbonyl]-, 1,1-diMethylethyl ester
N-(tert-Butoxycarbonyl)glycine tert-butyl ester
(tert-Butoxycarbonylamino)acetic acid tert-butyl ester | [EINECS(EC#)]
696-236-2 | [Molecular Formula]
C11H21NO4 | [MDL Number]
MFCD00191866 | [MOL File]
111652-20-1.mol | [Molecular Weight]
231.29 |
| Chemical Properties | Back Directory | [Melting point ]
66-68 °C(lit.)
| [Boiling point ]
306.0±25.0 °C(Predicted) | [density ]
1.023 | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
very soluble in Methanol | [form ]
powder to crystal | [pka]
11.06±0.46(Predicted) | [color ]
White to Almost white | [Water Solubility ]
1.05g/L at 20℃ | [BRN ]
5002580 | [InChIKey]
ZDKFMHKWZATBMR-UHFFFAOYSA-N | [LogP]
2.21 at 25℃ |
| Hazard Information | Back Directory | [Chemical Properties]
Whtie powder | [Uses]
peptide synthesis | [reaction suitability]
reaction type: Boc solid-phase peptide synthesis | [Synthesis]
Example 1 (Example of reaction formula (1)) [13]: tert-butyl glycinate hydrochloride (10.0 g, 59.7 mmol) was suspended in toluene (46.2 ml), heated to 60 °C and then triethylamine (6.51 g, 64.3 mmol) was added, and the reaction was stirred for 0.5 hours. Subsequently, a solution of di-tert-butyl dicarbonate (10.0 g, 45.9 mmol) in toluene (11.6 ml) was added slowly and dropwise to the reaction mixture and the reaction was continued for 6 hours. After completion of the reaction, it was quenched by addition of water (30 ml) and the organic layer was separated. The organic layer was distilled by azeotropic distillation with n-hexane to remove the solvent to afford tert-butyl N-Boc-glycinate (10.6 g, 45.9 mmol, 100% yield). The structure of the product was confirmed by 1H-NMR analysis. | [References]
[1] Patent: CN103068795, 2016, B. Location in patent: Paragraph 0119; 0120; 0121; 0122; 0123; 0124
[2] Synthesis, 1987, # 3, p. 223 - 225
[3] The Journal of organic chemistry, 2002, vol. 67, # 24, p. 8291 - 8298 |
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