| Identification | Back Directory | [Name]
OGERIN NEGATIVE CONTROL | [CAS]
1125453-08-8 | [Synonyms]
OGERIN NEGATIVE CONTROL
Ogerin negative control >=98% (HPLC)
Benzenemethanol, 3-[4-amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]- | [Molecular Formula]
C17H17N5O | [MDL Number]
MFCD29472590 | [MOL File]
1125453-08-8.mol | [Molecular Weight]
307.35 |
| Chemical Properties | Back Directory | [Boiling point ]
623.8±65.0 °C(Predicted) | [density ]
1.332±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 20mg/mL, clear | [form ]
powder | [pka]
14.14±0.10(Predicted) | [color ]
white to beige | [InChI]
1S/C17H17N5O/c18-16-20-15(14-8-4-7-13(9-14)11-23)21-17(22-16)19-10-12-5-2-1-3-6-12/h1-9,23H,10-11H2,(H3,18,19,20,21,22) | [InChIKey]
RVKAHYFWSKSSQQ-UHFFFAOYSA-N | [SMILES]
NC1=NC(C2=CC(CO)=CC=C2)=NC(NCC3=CC=CC=C3)=N1 |
| Hazard Information | Back Directory | [Uses]
Ogerin analogue 1 (compound 20) is a structural analog of Ogerin (HY-110279). Ogerin analogue 1 is generally used as a negative control[1]. | [Biochem/physiol Actions]
Ogerin negative control is a structurally similar analog of ogerin (catalog no. SML1482). Ogerin is a selective positive allosteric modulator of an orphan GPCR, GPR68, also known as Ovarian cancer G-protein coupled receptor 1 (OGR1). GPR68 is one of the proton or pH-sensing GPCRs that sense extracellular H(+). Ogerin potently potentiated proton-mediated GPR68-Gs signaling. The meta-analog is inactive and serves as a negative control. | [References]
[1] Yu X, et al. Design, Synthesis, and Characterization of Ogerin-Based Positive Allosteric Modulators for G Protein-Coupled Receptor 68 (GPR68). J Med Chem. 2019 Aug 22;62(16):7557-7574. DOI:10.1021/acs.jmedchem.9b00869 |
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