| Identification | Back Directory | [Name]
Ogerin | [CAS]
1309198-71-7 | [Synonyms]
Ogerin
Ogerin >=98% (HPLC)
2-[4-Amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]benzenemethanol
Benzenemethanol, 2-[4-amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]- | [Molecular Formula]
C17H17N5O | [MOL File]
1309198-71-7.mol | [Molecular Weight]
307.35 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: 50 mg/ml | [form ]
powder | [color ]
white to beige | [InChI]
1S/C17H17N5O/c18-16-20-15(14-9-5-4-8-13(14)11-23)21-17(22-16)19-10-12-6-2-1-3-7-12/h1-9,23H,10-11H2,(H3,18,19,20,21,22) | [InChIKey]
MDGIEDNDSFMSLP-UHFFFAOYSA-N | [SMILES]
OCC1=C(C2=NC(NCC3=CC=CC=C3)=NC(N)=N2)C=CC=C1 |
| Hazard Information | Back Directory | [Uses]
Ogerin is a potent GPR68 modulator. | [Biochem/physiol Actions]
Ogerin is a selective positive allosteric modulator of an orphan GPCR, GPR68, also known as Ovarian cancer G-protein coupled receptor 1 (OGR1). GPR68 is one of the proton or pH-sensing GPCRs that sense extracellular H(+). Ogerin potently potentiated proton-mediated GPR68-Gs signaling. Ogerin was not active in GPR68 knockout mice, but was found to suppress recall in fear conditioning in wild-type mice, showing an unexpected effect of GPR68 on learning and memory. | [Enzyme inhibitor]
This GPR68 activator (FW = 307.35 g/mol; CAS 1309198-71-7), also named 2-[4-amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]benzenemethanol, selectively and allosterically targets G-Protein-coupled Receptor 68, one of at least 120 non-olfactory G-protein-coupled receptors in the human genome that remain 'orphans' (i.e., they are pharmacologically dark, with no known endogenous ligands). Ogerin suppresses recall in fear conditioning in wild-type, but not in GPR68-knockout mice. GPR68 is also a newly recognized metastasis suppressor gene in certain cancers. | [in vivo]
Ogerin (10 mg/kg; single) shows effects that supports a role for GPR68 in hippocampal-associated memory[2]. | Animal Model: | GPR68 knockout and WT mice[2]. | | Dosage: | 10 mg/kg | | Administration: | Single (30 min before the training) | | Result: | Suppressed recall in fear conditioning in wild-type, but not in GPR68 knockout mice. |
| [storage]
Store at -20°C |
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