| Chemical Properties | Back Directory | [Boiling point ]
541.9±50.0 °C(Predicted) | [density ]
1.145±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 250 mg/mL (752.11 mM) | [form ]
Solid | [pka]
13.41±0.46(Predicted) | [color ]
Light yellow to khaki |
| Hazard Information | Back Directory | [Uses]
ROCK inhibitor-2 (compound 6) is a selective dual inhibitor of ROCK1 and ROCK2, with IC50 values of 160 nM and 21 nM, respectively. ROCK inhibitor-2 inhibits pMYPT1 with IC50 of 75 nM. ROCK inhibitor-2 exhibits antitumor activity[1][2]. | [in vivo]
ROCK inhibitor-2 (10 mg/kg*day, ip, 27 days) exhibits antitumor efficacy in U2OS xenograft mouse models[2]. | Animal Model: | U2OS xenograft mouse models[2] | | Dosage: | 10 mg/kg*day | | Administration: | ip, 27 days | | Result: | Inhibited tumor growth. |
| [IC 50]
ROCK1: 160 nM (IC50); ROCK2: 21 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Hobson AD, et al. Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based DrugDesign. J Med Chem. 2018 Dec 27;61(24):11074-11100. DOI:10.1021/acs.jmedchem.8b01098
[2] Zhang W, et al., 3D-printing magnesium-polycaprolactone loaded with melatonin inhibits the development of osteosarcoma by regulating cell-in-cell structures. J Nanobiotechnology. 2021 Sep 4;19(1):263. DOI:10.1186/s12951-021-01012-1 |
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