| Chemical Properties | Back Directory | [Boiling point ]
891.1±65.0 °C(Predicted) | [density ]
1.200±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
11.12±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Z-LEVD-FMK is a cell-permeable caspase-4 inhibitor. Z-LEVD-FMK blocks ER stress-induced apoptosis in cancer cells[1]. | [IC 50]
Caspase-4 | [References]
[1] Bian ZM, et al. Dual involvement of caspase-4 in inflammatory and ER stress-induced apoptotic responses in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2009 Dec;50(12):6006-14. DOI:10.1167/iovs.09-3628
[2] Ariazi EA, et al. Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time. Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):18879-86. DOI:10.1073/pnas.1115188108 |
|
| Company Name: |
YantaiBio
|
| Tel: |
13758194781 |
| Website: |
|
|