| Identification | Back Directory | [Name]
NF-kB Activation Inhibitor VI, BOT-64 | [CAS]
113760-29-5 | [Synonyms]
BOT-64
NF-kappaB Activation Inhibitor VI
NFκB Activation Inhibitor VI, BOT-64
NF-kB Activation Inhibitor VI, BOT-64
6,7-Dihydro-6,6-dimethyl-2-(phenylimino)-1,3-benzoxathiol-4(5H)-one
NF-κB Activation Inhibitor VI, BOT-64 - CAS 113760-29-5 - Calbiochem
1,3-Benzoxathiol-4(5H)-one, 6,7-dihydro-6,6-dimethyl-2-(phenylimino)-
(Z)-6,6-dimethyl-2-(phenylimino)-6,7-dihydrobenzo[d][1,3]oxathiol-4(5H)-one
IL-6,BOT64,I kappa B kinase,inhibit,inflammatory,BOT-64,NF-κb,RAW 264.7,IKK,IκB kinase,Inhibitor,BOT 64 | [Molecular Formula]
C15H15NO2S | [MOL File]
113760-29-5.mol | [Molecular Weight]
273.35 |
| Chemical Properties | Back Directory | [Boiling point ]
402.1±48.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
-20C | [solubility ]
Soluble in ethanol or DMSO | [form ]
Off-white solid | [pka]
0.25±0.40(Predicted) | [color ]
Off-white to light yellow | [Sensitive ]
Light Sensitive |
| Hazard Information | Back Directory | [Uses]
A cell-permeable benzoxathiole compound that acts as an IKK-2 inhibitor | [in vivo]
BOT-64 (3-30 mg/kg) increases the survival rates of endotoxin LPS-shocked mice[1]. | [IC 50]
IKKβ: 1 μM (IC50) |
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