| Identification | Back Directory | [Name]
4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine ethyl ester N-benzoylglycine salt | [CAS]
1137608-69-5 | [Synonyms]
CS-373
Telotristat,LX1606
Telotristat etiprate
Telotristatethylhippurate
Telotristat Etiprate （API）
Telotristat Etiprate, >=98%
Telotristat Ethyl Etiprate Salt
LX 1606 hippurate(Telotristat etiprate)
Telotristat Etiprate (LX 1606 Hippurate)
LX 1032 hippurate / Telotristat etiprate
Telotristat Etiprate , LP778902 hippurate salt
LX1606 HIPPURATE;TELOTRISTAT ETIPRATE;LX-1606 HIPPURATE
TELOTRISTAT ETIPRATE; LX 1606 HIPPURATE; LX-1606 HIPPURATE
2-Benzamidoacetic acid, ((S)-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phen
(S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate hippurate
4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine ethyl ester N-benzoylglycine salt
ethyl (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate benzoylglycinate
4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine ethyl ester N-benzoylglycine salt USP/EP/BP
L-Phenylalanine, 4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-, ethyl ester, compd. with N-benzoylglycine (1:1) | [Molecular Formula]
C36H35ClF3N7O6 | [MDL Number]
MFCD22741520 | [MOL File]
1137608-69-5.mol | [Molecular Weight]
754.155 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C, protected from light | [solubility ]
DMSO:59.33(Max Conc. mg/mL);78.67(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.44(Max Conc. mM)
DMF:50.0(Max Conc. mg/mL);66.3(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);6.63(Max Conc. mM) | [form ]
Powder | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Telotristat Etiprate is a solid orally bioavailable tryptophan hydroxylase (TPH) inhibitor. | [in vivo]
Telotristat ethyl (15, 50, 150, 300 mg/kg, po, qd) reduces serotonin content in the periphery, but not in the brain of the mice. Telotristat ethyl (200 mg/kg po, qd) prevents the increase in blood neutrophil counts that is observed after TNBS challenge, provides significant protection in a mouse model of inflammatory bowel disease. Telotristat ethyl (200 mg/kg po, qd) protects the mouse IBD model confirmed by histopathology evaluation[1].
Telotristat ethyl (15, 50, 150, 300 mg/kg) depletes 5-HT from the jejunum but not the brain. But Telotristat ethyl (200 mg/kg, p.o.) does not deplete enteric neuronal serotonin (5-HT), or alter constitutive gastrointestinal motility in mice. Telotristat ethyl (200 mg/kg) alleviates the severity of trinitrobenzene sulfonic acid (TNBS)-induced colitis[2]. | [storage]
Store at -20°C, protected from light |
|
|