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1140964-99-3

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1140964-99-3 Structure

1140964-99-3 Structure
IdentificationBack Directory
[Name]

E-7449
[CAS]

1140964-99-3
[Synonyms]

E7449
E-7449
E7449;E 7449
8-(1,3-dihydro-isoindol-2-ylmethyl)-2,9-dihydro-1,2,7,9-tetraaza-phenalen-3-one
3H-Pyridazino[3,4,5-de]quinazolin-3-one, 8-[(1,3-dihydro-2H-isoindol-2-yl)methyl]-1,2-dihydro-
[Molecular Formula]

C18H15N5O
[MDL Number]

MFCD28167842
[MOL File]

1140964-99-3.mol
[Molecular Weight]

317.34
Chemical PropertiesBack Directory
[density ]

1.53±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO:0.2(Max Conc. mg/mL);0.63(Max Conc. mM)
[form ]

A crystalline solid
[pka]

9.51±0.20(Predicted)
[color ]

Light yellow to yellow
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)Health Hazard (GHS08)Environment (GHS09)
GHS07,GHS08,GHS09
[Signal word ]

Danger
[Hazard statements ]

H302-H400-H410-H372
[Precautionary statements ]

P264-P270-P273-P301+P312-P330-P391-P501
Hazard InformationBack Directory
[Uses]

E 7449 is a dual inhibitor of PARP1/2 and tankyrase1/2 exhibits anti-tumor activity in BRCA-deficient in vivo models. PARP1/2 and tankyrase1/2 are involved with DNA damage and canonical Wnt/β-catenin signaling, respectively.
Spectrum DetailBack Directory
[Spectrum Detail]

E-7449(1140964-99-3)1HNMR
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