| Chemical Properties | Back Directory | [density ]
1.404±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
0.1 M HCl: 25 mg/ml,DMSO: 50 mg/ml | [form ]
A solid | [pka]
5.50±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
AZ-GHS-22 is a potent, non-CNS penetrant GHS-R1a inverse agonist (IC50=0.77 nM)[1]. | [Biological Activity]
AZ-GHS-22 is an inverse agonist of the growth hormone secretagogue receptor 1a (GHS-R1a), which is also known as the ghrelin receptor.1 It binds to GHS-R1a with an IC50 value of 0.77 nM. AZ-GHS-22 decreases food intake in mice by 54% in the first two hours after administration of a 100 mg/kg dose. | [storage]
-20°C | [References]
1.McCoull, W., Barton, P., Brown, A.J.H., et al.Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonistsJ. Med. Chem.57(14)6128-6140(2014)
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
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