| Identification | Back Directory | [Name]
N-(Iodoacetamido)-Doxorubicin | [CAS]
114390-30-6 | [Synonyms]
N-(Iodoacetamido)-Doxorubicin | [Molecular Formula]
C29H30INO12 | [MDL Number]
MFCD32693351 | [MOL File]
114390-30-6.mol | [Molecular Weight]
711.45 |
| Chemical Properties | Back Directory | [Boiling point ]
930.1±65.0 °C(Predicted) | [density ]
1.82±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DMF | [pka]
7.35±0.60(Predicted) |
| Hazard Information | Back Directory | [Description]
N-(Iodoacetamido)-Doxorubicin is an iodine attached Doxorubicin. It can conjugate with molecules containing thiol, amine functional groups. Doxorubicin is an anthracycline antibiotic with antineoplastic activity | [Uses]
N-(Iodoacetamido)-Doxorubicin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | [IC 50]
Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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