| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (142.13 mM; Need ultrasonic)| (insoluble) | [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
Water : < 0.1 mg/mL (ultrasonic;adjust pH to 1 with 1M HCl) | [InChIKey]
FTUVYXYASCIRPX-MFIMTQMYNA-N | [SMILES]
C(N1N(CC(=O)N2[C@H](C(=O)N(CC3C=CC=C4C=NNC=34)C[C@]12[H])CC1C=CC(OP(O)(O)=O)=CC=1)CC=C)(=O)NCC1C=CC=CC=1.[NaH] |&1:7,22,r| |
| Hazard Information | Back Directory | [Uses]
YB-0158 (Wnt pathway inhibitor 2) is a reverse-turn peptidomimetic and a potent colorectal cancer stem cell (CSC) targeting agent. YB-0158 disrupts Sam68-Src interactions and induces apoptosis in CRC cells. Anti-cancer activities[1]. | [in vivo]
YB-0158 displays an EC50 (1.64 μM) in cultured MC38 cells. YB-0158 (100 mg/kg; IP; C57BL/6 mice bearing MC38 cells) shows no significant differences in primary tumor size in vivo treatments versus saline controls[2]. | [storage]
Store at -20°C | [References]
[1] Masibag AN, Bergin CJ, Haebe JR, et al. Pharmacological targeting of Sam68 functions in colorectal cancer stem cells. iScience. 2021;24(12):103442. DOI:10.1016/j.isci.2021.103442 |
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