| Identification | Back Directory | [Name]
2-amino-8-(2-morpholinoethoxy)-4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one | [CAS]
1147271-25-7 | [Synonyms]
2-amino-8-(2-morpholinoethoxy)-4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one
5H-Indeno[1,2-d]pyrimidin-5-one, 2-amino-8-[2-(4-morpholinyl)ethoxy]-4-phenyl- | [Molecular Formula]
C23H22N4O3 | [MDL Number]
MFCD18800878 | [MOL File]
1147271-25-7.mol | [Molecular Weight]
402.446 |
| Hazard Information | Back Directory | [Description]
JNJ-40255293 is an adenosine A2A/A1 antagonist with efficacy in preclinical models of parkinson's disease. | [Uses]
JNJ-40255293 is a high-affinity human A 2A receptor antagonist with a KiKi of 7.5 nM. JNJ-40255293 can be used in the research of neurodegenerative diseases such as Parkinson's disease[1]. | [in vivo]
JNJ-40255293 (0.1-10 mg/kg, p.o.) can reverse haloperidol (HY-14538)-induced catalepsy in male Balb/c mice. In male Wistar rats, JNJ-40255293 also dose-dependently reversed haloperidol (0.63 mg/kg, subcutaneous injection)-induced catalepsy, enhanced active arousal, and significantly reversed reserpine (HY-N0480 ) caused deficits in motor activity[1].
| [References]
[1] John R Atack, et al. JNJ-40255293, a novel adenosine A2A/A1 antagonist with efficacy in preclinical models of Parkinson's disease. ACS Chem Neurosci. 2014 Oct 15;5(10):1005-19. DOI:10.1021/cn5001606 |
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