| Identification | More | [Name]
BOC-L-2-Fluorophe | [CAS]
114873-00-6 | [Synonyms]
BOC-2-FLUORO-L-PHE
BOC-2-FLUORO-L-PHENYLALANINE
BOC-L-2-FLUOROPHE
BOC-L-2-FLUOROPHENYLALANINE
BOC-L-PHE(2-F)-OH
BOC-O-FLUORO-PHE-OH
BOC-PHE(2-F)-OH
BOC-PHE(O-F)-OH
BOC-(S)-2-AMINO-3-(2'-FLUOROPHENYL)PROPANOIC ACID
L-2-FLUOROPHENYLALANINE, BOC PROTECTED
N-ALPHA-T-BUTOXYCARBONYL-L-2-FLUOROPHENYLALANINE
N-ALPHA-TERT-BUTYLOXYCARBONYL-L-2-FLUOROPHENYLALANINE
N-TERT-BUTOXYCARBONYL-2-FLUOROPHENYL-L-ALANINE
RARECHEM BK PT 0020
(S)-2-TERT-BUTOXYCARBONYLAMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID
(S)-N-BOC-2-FLUOROPHENYLALANINE
tert-Butoxycarbonyl-L-2-fluorophenylalanine
L-2-Fluorophenylalanine, N-BOC protected
N-alpha-tert-Butoxycarbonyl-3-(2-fluorophenyl)-L-al
N-tert-Butoxycarbonyl-L-Fluoro Phenylalanine | [EINECS(EC#)]
220-105-7 | [Molecular Formula]
C14H18FNO4 | [MDL Number]
MFCD00672520 | [Molecular Weight]
283.3 | [MOL File]
114873-00-6.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powde | [Melting point ]
92-96 °C | [alpha ]
10 º (c=1,EtOAc) | [Boiling point ]
427.3±40.0 °C(Predicted) | [density ]
1.1918 (estimate) | [storage temp. ]
Keep Cold | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
3.87±0.11(Predicted) | [Optical Rotation]
[α]20/D +9±1°, c = 1% in ethyl acetate | [BRN ]
5347990 | [Major Application]
peptide synthesis | [InChI]
1S/C14H18FNO4/c1-14(2,3)20-13(19)16-11(12(17)18)8-9-6-4-5-7-10(9)15/h4-7,11H,8H2,1-3H3,(H,16,19)(H,17,18)/t11-/m0/s1 | [InChIKey]
NTWUXBKUDXGMHV-NSHDSACASA-N | [SMILES]
CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1F)C(O)=O | [CAS DataBase Reference]
114873-00-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [Hazard Note ]
Irritant/Keep Cold | [HS Code ]
2922498590 | [Storage Class]
13 - Non Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powde | [Uses]
peptide synthesis | [reaction suitability]
reaction type: Boc solid-phase peptide synthesis | [Synthesis]
General steps:
1. 2-Fluoro-L-phenylalanine (1.00 g) was dissolved in a mixture of dioxane (10 ml) and water (5 ml) under cooling conditions in an ice bath.
2. 1N aqueous sodium hydroxide solution (5.46 ml) and di-tert-butyl dicarbonate (1.38 ml) were slowly added to the above solution, keeping the reaction system in an ice bath.
3. The ice bath was removed and the reaction mixture was stirred at room temperature for 1 hour.
4. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure to remove the organic solvent.
5. The pH of the concentrate was adjusted to 2.5 with dilute hydrochloric acid. 6.
6. The aqueous phase was extracted with ethyl acetate (100 ml x 3) and the organic phases were combined.
7. Wash the organic phase with water and saturated saline in turn. 8.
8. Dry the organic phase with anhydrous sodium sulfate and filter to remove the desiccant.
9. The filtrate was concentrated under pressure to obtain the crude product.
10. The crude product was recrystallized with ethyl acetate-petroleum ether mixed solvent to obtain N-Boc-2-fluoro-L-phenylalanine (1.32 g, 85% yield) as colorless crystals. | [References]
[1] Patent: US5556853, 1996, A
[2] Journal of Medicinal Chemistry, 1994, vol. 37, # 13, p. 2090 - 2099 |
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Alfa Aesar
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RYSS TECH LTD
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