| Identification | Back Directory | [Name]
1',3'-bis[1,2-dioleoyl-sn-glycero-3-phospho]-sn-glycerol (sodiuM salt) | [CAS]
115404-77-8 | [Synonyms]
18:1 Cardiolipin
1',3'-bis[1,2-dioleoyl-sn-glycero-3-phospho]-sn-glycerol (sodiuM salt)
1',3'-BIS[1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHO]-SN-GLYCEROL (SODIUM SALT);18:1 CARDIOLIPIN | [Molecular Formula]
C81H151NaO17P2 | [MOL File]
115404-77-8.mol | [Molecular Weight]
1482.02 |
| Hazard Information | Back Directory | [Uses]
1'',?3''-?bis[1,?2-?Dioleoyl-?sn-?glycero-?3-?phospho]?-?glycerol Sodium Salt is used as a pharmaceutical compound for inhibition of inflammation. | [Biological Activity]
Cardiolipin (CL) plays a key role in coordinating energy metabolism in eukaryotes. Metabolic defect in the CL pathway is implicated in dilated cardiomyopathy. CL is essential for mitochondrial functions and apoptosis. Alternations in CL content and their acyl chain compositioncontributes to mitochondrial dysfunction in various pathological conditions.''Cardiolipin is involved in the dynamic organization of membranes and in cell division. It modulates the proton uptake pathway. Cardiolipin plays a critical role in mitochondrial biogenesisfusion and fissionrespiration and protein import. It controls cell wall biogenesisvacuole homeostasisagingcell cycle and apoptosis.''Cardiolipin participates in proton uptake pathway and also maintains the struc | [References]
[1] ÁLVAREZ-BENEDICTO E, FARBIAK L, RAMÍREZ M M, et al. Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA)†[J]. Biomaterials Science, 2021, 2: 549-559. DOI: 10.1039/d1bm01454d |
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