| Identification | Back Directory | [Name]
2-Naphthalenecarboxylic acid, 4-[4-(4-piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-, methanesulfonate (1:1) | [CAS]
1160271-31-7 | [Synonyms]
PPTN Mesylate
PPTN Mesylate salt
2-Naphthalenecarboxylic acid, 4-[4-(4-piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-, methanesulfonate (1:1) | [Molecular Formula]
C30H28F3NO5S | [MOL File]
1160271-31-7.mol | [Molecular Weight]
571.61 |
| Hazard Information | Back Directory | [Description]
PPTN Mesylate is a potent and highly selective antagonist of the P2Y14 receptor (P2Y14R), one of eight P2Y G protein-coupled receptors. | [Uses]
PPTN mesylate is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. PPTN mesylate exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and immune activity[1]. | [References]
[1] Barrett MO, et al. A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol Pharmacol. 2013 Jul;84(1):41-9. DOI:10.1124/mol.113.085654
[2] Lin J, et al. The P2Y14 receptor in the trigeminal ganglion contributes to the maintenance of inflammatory pain. Neurochem Int. 2019 Dec;131:104567. DOI:10.1016/j.neuint.2019.104567 |
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