| Identification | Back Directory | [Name]
2-Amino-6-bromothiazolo[5,4-b]pyridine | [CAS]
1160791-13-8 | [Synonyms]
2-Amino-6-bromothiazolo[5,4-b]pyridine
6-BroMo-thiazolo[5,4-b]pyridin-2-ylaMine
Thiazolo[5,4-b]pyridin-2-amine, 6-bromo- | [Molecular Formula]
C6H4BrN3S | [MDL Number]
MFCD11846628 | [MOL File]
1160791-13-8.mol | [Molecular Weight]
230.085 |
| Chemical Properties | Back Directory | [Boiling point ]
362.1±45.0 °C(Predicted) | [density ]
1.950±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
0.79±0.40(Predicted) | [Appearance]
Light brown to brown Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 2-amino-6-bromothiazolo[5,4-b]pyridin-2-yl from N-(6-bromothiazolo[5,4-b]pyridin-2-yl)benzamide: Dissolve N-(6-bromothiazolo[5,4-b]pyridin-2-yl)benzamide (2.0 g, 5.98 mmol) in 70% sulfuric acid (10.0 mL) and react by heating to 140 °C for 1 hour. Upon completion of the reaction (monitored by TLC), the reaction mixture was poured into crushed ice and the pH was adjusted to 8.0 with 30% aqueous sodium hydroxide, followed by extraction with ethyl acetate (3 x 150 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the target product 2-amino-6-bromothiazolo[5,4-b]pyridine (1.34 g, 98% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 7.85 (d, J=2.0 Hz, 1H), 8.05 (br s, 2H), 8.18 (d, J=2.0 Hz, 1H). | [References]
[1] Patent: WO2009/74812, 2009, A1. Location in patent: Page/Page column 91; 92 |
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| Company Name: |
NovoChemy Ltd.
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021-31261262/ 49 (0)17662837245 |
| Website: |
www.novochemy.com |
| Company Name: |
SynAsst Chemical.
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021-60343070 |
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www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm |
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