| Identification | More | [Name]
5-Acetonyl-2-methoxybenzene sulfonamide | [CAS]
116091-63-5 | [Synonyms]
2-METHOXY-5-(2-OXO-PROPYL)BENZENESULFONAMIDE
2-METHOXY-5-(2-OXOPROPYL)BENZENE SULPHONAMIDE
5-(2-OXOPROPYL)-2-METHOXY BENZENE SULPHONAMIDE
5-ACETONYL-2-METHOXYBENZENE SULFONAMIDE
5-ACETONYL-2-METHOXYBENZENE SULPHONAMIDE
5-(2-Oxypropyl)-2-methoxybenzenesulfonamide
5-(2-OXYPROPYL)-2-METHOXYBENZENE SULPHONAMIDE 98+%
5-(2-Oxypropyl)-2-methoxybenze
5-(2-OXPROPYL)-2-METHOXYBENZENESULPHONAMID
5-(2-Oxypropyl)-2-methoxybenzene sulphonamide | [EINECS(EC#)]
601-411-3 | [Molecular Formula]
C10H13NO4S | [MDL Number]
MFCD07782136 | [Molecular Weight]
243.28 | [MOL File]
116091-63-5.mol |
| Chemical Properties | Back Directory | [Melting point ]
194-197°C | [Boiling point ]
444.6±55.0 °C(Predicted) | [density ]
1.288±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
9.91±0.60(Predicted) | [color ]
Light Beige | [InChI]
InChI=1S/C10H13NO4S/c1-7(12)5-8-3-4-9(15-2)10(6-8)16(11,13)14/h3-4,6H,5H2,1-2H3,(H2,11,13,14) | [InChIKey]
MQQJFLHZXQRKKJ-UHFFFAOYSA-N | [SMILES]
C1(S(N)(=O)=O)=CC(CC(=O)C)=CC=C1OC | [CAS DataBase Reference]
116091-63-5(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
5-Acetonyl-2-methoxybenzene is used in the synthesis of tamsulosin, a drug used in benign prostatic hyperplasia therapy. | [Uses]
5-Acetonyl-2-methoxybenzene sulfonamide can be used as Tamsulosine intermediate.
| [Synthesis]
General procedure for the synthesis of 2-methoxy-5-(2-oxopropyl)benzenesulfonamide from 2-methoxy-5-(2-oxopropyl)benzenesulfonyl chloride: embodiment 6-comparison; method for the preparation of tamsulosin (II) according to the prior art as compared to the method comprising steps according to the present invention.1. Method according to the prior art: 1.1 According to US 4,731,478 (1988) , chlorosulfonation is carried out in two steps; 1.2 The yield of VII is 40% and the total yield of III is 30%. | [References]
[1] Patent: WO2005/75415, 2005, A1. Location in patent: Page/Page column 9
[2] Chemical and Pharmaceutical Bulletin, 1992, vol. 40, # 6, p. 1443 - 1451
[3] Patent: WO2003/72557, 2003, A1. Location in patent: Page/Page column 44-45
[4] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 16, p. 3714 - 3718
[5] Patent: CN106631918, 2017, A. Location in patent: Paragraph 0152-0156 |
|
|