| Identification | More | [Name]
(R)-3-Aminopyrrolidine | [CAS]
116183-82-5 | [Synonyms]
(3R)-()-3-AMINOPYRROLIDINE
(3R)-(+)-3-AMINOPYRROLIDINE
(3R)-(+)-AMINOPYRROLIDINE
PYRROLIDIN-(R)-3-YLAMINE
(R)-(+)-3-AMINOPYRROLIDINE
(R)-3-AMINOPYRROLIDINE
R-AP
3-amino-R-pyrrolidine
(3R)-3-Pyrrolidinamine
(3R)-(+)-3-AMINOPYRROLIDINE 98+%
(R)-pyrrolidin-3-amine
(3R)-Pyrrolidine-3-amine | [Molecular Formula]
C4H10N2 | [MDL Number]
MFCD00143190 | [Molecular Weight]
86.14 | [MOL File]
116183-82-5.mol |
| Chemical Properties | Back Directory | [Boiling point ]
164-165 °C(lit.) | [density ]
0.984 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.489(lit.)
| [Fp ]
147 °F
| [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
clear liquid | [pka]
9.94±0.20(Predicted) | [color ]
Colorless to Almost colorless | [Optical Rotation]
[α]/D +20°, neat | [CAS DataBase Reference]
116183-82-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
NA 1993 / PGIII | [WGK Germany ]
3
| [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of (S)-3-aminopyrrolidine from (S)-1-benzyl-3-aminopyrrolidine: 7.0 g of (S)-1-benzyl-3-aminopyrrolidine, 25 mL of methanol, and 0.7 g of 5% Pd/C catalyst were added to a 100 mL autoclave. The hydrogen pressure was adjusted to 1 MPa, the temperature was raised to 70 °C and the reaction was kept stirring for 8 hours. Upon completion of the reaction, it was cooled to room temperature and the pressure was slowly released. The reaction mixture was filtered to remove the catalyst and the mother liquor was concentrated and purified by distillation to collect the 80-83 °C/40 kPa fraction to give 3.2 g of (S)-3-aminopyrrolidine. The product was analyzed with 99% chemical purity and 90% optical purity e.e. | [References]
[1] Patent: US6348600, 2002, B1. Location in patent: Page column 14
[2] Patent: EP1640364, 2006, A1. Location in patent: Page/Page column 10
[3] Patent: EP1236716, 2002, A1. Location in patent: Example 6 |
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